Association of plasma des-acyl ghrelin levels with CKD.

ABSTRACT:

Background and objectives

There are no effective therapies for malnutrition in CKD/ESRD patients. This study hypothesized that ghrelin, an endogenous orexigenic hormone, would correlate with renal function and might suggest therapeutic interventions for CKD/ESRD malnutrition.

Design, setting, participants, & measurements

Fifty-one CKD and 15 hemodialysis patients were enrolled. Acyl ghrelin (AG) and des-acyl ghrelin (DG) were determined using separate two-site-specific assays. Leptin, insulin, growth hormone, insulin-link growth factor-1, C-reactive protein, TNF-α, and IL-6 were also measured.

Results

Univariate correlation analyses showed that CKD stage was highly, positively correlated with the levels of preprandial and postprandial DG and positively correlated with

SUBMITTER: Gupta RK 

PROVIDER: S-EPMC3700692 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature