24-hour urine phosphorus excretion and mortality and cardiovascular events.

ABSTRACT:

Background and objectives

Higher morning serum phosphorus has been associated with cardiovascular disease (CVD) in patients with or without CKD. In patients with CKD and a phosphorous level >4.6 mg/dl, the Kidney Disease Improving Global Outcomes guidelines recommend dietary phosphorus restriction. However, whether phosphorus restriction influences serum phosphorus concentrations and whether dietary phosphorus is itself associated with CVD or death are uncertain.

Design, setting, participants, & measurements

Among 880 patients with stable CVD and normal kidney function to moderate CKD, 24-hour urine phosphorus excretion (UPE) and serum phosphorus were measured at baseline. Participants were followed for a median of 7.4 years for CVD events and all-cause mortality.

Results

SUBMITTER: Palomino HL 

PROVIDER: S-EPMC3700702 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature