An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue.

ABSTRACT:

Background

Cilia are found on nearly every cell type in the mammalian body, and have been historically classified as either motile or immotile. Motile cilia are important for fluid and cellular movement; however, the roles of non-motile or primary cilia in most tissues remain unknown. Several genetic syndromes, called the ciliopathies, are associated with defects in cilia structure or function and have a wide range of clinical presentations. Much of what we know about the formation and maintenance of cilia comes from model systems like C. elegans and Chalmydomonas. Studies of mammalian cilia in live tissues have been hampered by difficulty visualizing them.

Results

To facilitate analyses of mammalian cilia function we generated an inducible CiliaGFP mouse by targeting mouse

SUBMITTER: O'Connor AK 

PROVIDER: S-EPMC3700774 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature