Alternative splicing tends to avoid partial removals of protein-protein interaction sites.

ABSTRACT:

Background

Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS.

Results

Using a Cochr

SUBMITTER: Colantoni A 

PROVIDER: S-EPMC3700808 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature