A fungal endophyte induces transcription of genes encoding a redundant fungicide pathway in its host plant.

ABSTRACT:

Background

Taxol is an anti-cancer drug harvested from Taxus trees, proposed ecologically to act as a fungicide. Taxus is host to fungal endophytes, defined as organisms that inhabit plants without causing disease. The Taxus endophytes have been shown to synthesize Taxol in vitro, providing Taxus with a second potential biosynthetic route for this protective metabolite. Taxol levels in plants vary 125-fold between individual trees, but the underlying reason has remained unknown.

Results

Comparing Taxus trees or branches within a tree, correlations were observed between Taxol content, and quantity of its resident Taxol-producing endophyte, Paraconiothyrium SSM001. Depletion of fungal endophyte in planta by fungicide reduced plant Taxol accumulation. Fungicide treatment of int

SUBMITTER: Soliman SS 

PROVIDER: S-EPMC3700885 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature