Pyruvate oxidase influences the sugar utilization pattern and capsule production in Streptococcus pneumoniae.

ABSTRACT: Pyruvate oxidase is a key function in the metabolism and lifestyle of many lactic acid bacteria and its activity depends on the presence of environmental oxygen. In Streptococcus pneumoniae the protein has been suggested to play a major role in metabolism and has been implicated in virulence, oxidative stress survival and death in stationary phase. Under semi-aerobic conditions, transcriptomic and metabolite profiling analysis of a spxB mutant grown on glucose showed minor changes compared to the wild type, apart from the significant induction of two operons involved in carbohydrate uptake and processing. This induction leads to a change in the sugar utilization capabilities of the bacterium, as indicated by the analysis of the growth profiles of the D39 parent and spxB mutant on alternati

SUBMITTER: Carvalho SM 

PROVIDER: S-EPMC3701046 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature