Ontology highlight
ABSTRACT:
SUBMITTER: Morgani SM
PROVIDER: S-EPMC3701323 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Cell reports 20130606 6
Embryonic stem cells (ESCs) are derived from mammalian embryos during the transition from totipotency, when individual blastomeres can make all lineages, to pluripotency, when they are competent to make only embryonic lineages. ESCs maintained with inhibitors of MEK and GSK3 (2i) are thought to represent an embryonically restricted ground state. However, we observed heterogeneous expression of the extraembryonic endoderm marker Hex in 2i-cultured embryos, suggesting that 2i blocked development p ...[more]