Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy.

ABSTRACT:

Background

Renal interstitial fibrosis and glomerular sclerosis are hallmarks of diabetic nephropathy (DN) and several studies have implicated members of the WNT pathways in these pathological processes. This study comprehensively examined common genetic variation within the WNT pathway for association with DN.

Methods

Genes within the WNT pathways were selected on the basis of nominal significance and consistent direction of effect in the GENIE meta-analysis dataset. Common SNPs and common haplotypes were examined within the selected WNT pathway genes in a white population with type 1 diabetes, discordant for DN (cases: n = 718; controls: n = 749). SNPs were genotyped using Sequenom or Taqman assays. Association analyses were performed using PLINK, to compare allele and hap

SUBMITTER: Kavanagh DH 

PROVIDER: S-EPMC3701522 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature