Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis.

ABSTRACT:

Background

Depression is characterised partly by blunted reactions to reward. However, tasks probing this deficiency have not distinguished insensitivity to reward from insensitivity to the prediction errors for reward that determine learning and are putatively reported by the phasic activity of dopamine neurons. We attempted to disentangle these factors with respect to anhedonia in the context of stress, Major Depressive Disorder (MDD), Bipolar Disorder (BPD) and a dopaminergic challenge.

Methods

Six behavioural datasets involving 392 experimental sessions were subjected to a model-based, Bayesian meta-analysis. Participants across all six studies performed a probabilistic reward task that used an asymmetric reinforcement schedule to assess reward learning. Healthy controls

SUBMITTER: Huys QJ 

PROVIDER: S-EPMC3701611 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature