Effects of late gestational high-fat diet on body weight, metabolic regulation and adipokine expression in offspring.

ABSTRACT:

Aims/hypothesis

Gestational exposures such as dietary changes can alter offspring phenotype through epigenetic modifications and promote increased risk for specific diseases, such as metabolic syndrome. We hypothesized that high-fat diet (HFD) during late gestation would lead increased risk for insulin resistance and hyperlipidemia via associated epigenetic alterations in tissue adipocytokine genes.

Methods

Offspring mice of mothers fed a HFD during late gestation (HFDO) were weighed and their food intake measured weekly till age 20 weeks at which time glucose and insulin tolerance tests, plasma lipid and adipocytokine levels were assessed, as well as mRNA expression in visceral fat. Adipocytokine gene methylation levels in visceral fat, liver and muscle were also assayed.

SUBMITTER: Khalyfa A 

PROVIDER: S-EPMC3701742 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature