Prion-like propagation of protein aggregation and related therapeutic strategies.

ABSTRACT: Many neurodegenerative diseases are characterized by the progressive accumulation of aggregated protein. Recent evidence suggests the prion-like propagation of protein misfolding underlies the spread of pathology observed in these diseases. This review traces our understanding of the mechanisms that underlie this phenomenon and discusses related therapeutic strategies that derive from it.

SUBMITTER: Kaufman SK 

PROVIDER: S-EPMC3701767 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature