Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome.

ABSTRACT:

Background

There is no consistent evidence of specific gene(s) or molecular pathways that contribute to the pathogenesis, therapeutic intervention or diagnosis of chronic fatigue syndrome (CFS). While multiple studies support a role for genetic variation in CFS, genome-wide efforts to identify associated loci remain unexplored. We employed a novel convergent functional genomics approach that incorporates the findings from single-nucleotide polymorphism (SNP) and mRNA expression studies to identify associations between CFS and novel candidate genes for further investigation.

Methods

We evaluated 116,204 SNPs in 40 CFS and 40 nonfatigued control subjects along with mRNA expression of 20,160 genes in a subset of these subjects (35 CFS subjects and 27 controls) derived from a po

SUBMITTER: Smith AK 

PROVIDER: S-EPMC3701888 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature