Blocking HIV-1 gp120 at the Phe43 cavity: if the extension fits….

ABSTRACT: The Phe43 cavity is a mysterious feature in crystallographic structures of HIV-1 gp120-CD4 complexes. In this issue of Structure, Acharya and colleagues provide structural explanations for the potent neutralization by CD4 mimetic miniproteins with chemical extensions that fit into this cavity.

SUBMITTER: Dey B 

PROVIDER: S-EPMC3701939 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature