Pivotal regulatory network and genes in osteosarcoma.

ABSTRACT:

Introduction

Understanding the transcriptional regulatory networks that map out the coordinated responses of transcription factors and target genes would represent a significant advance in the analysis of osteosarcoma, a common primary bone malignancy. The objective of our study was to interpret the mechanisms of osteosarcoma through the regulation network construction.

Material and methods

Using GSE14359 datasets downloaded from Gene Expression Omnibus data, we first screened the differentially expressed genes in osteosarcoma. We explored the regulation relationship between transcription factors and target genes using Cytoscape. The underlying molecular mechanisms of these crucial target genes were investigated by Gene Ontology function and Kyoto Encyclopedia of Genes and G

SUBMITTER: Luo Y 

PROVIDER: S-EPMC3701964 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature