Variants at the 9p21 locus and melanoma risk.

ABSTRACT:

Background

The influence of variants at the 9p21 locus on melanoma risk has been reported through investigation of CDKN2A variants through candidate gene approach as well as by genome wide association studies (GWAS).

Methods

In the present study we genotyped, 25 SNPs that tag 273 variants on chromosome 9p21 in 837 melanoma cases and 1154 controls from Spain. Ten SNPs were selected based on previous associations, reported in GWAS, with either melanocytic nevi or melanoma risk or both. The other 15 SNPs were selected to fine map the CDKN2A gene region.

Results

All the 10 variants selected from the GWAS showed statistically significant association with melanoma risk. Statistically significant association with melanoma risk was also observed for the carriers of the varian

SUBMITTER: Maccioni L 

PROVIDER: S-EPMC3702420 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature