A new transcriptional repressor of the pseudomonas aeruginosa quorum sensing receptor gene lasR.

ABSTRACT: Pseudomonas aeruginosa pathogenic potential is controlled via multiple regulatory pathways, including three quorum sensing (QS) systems. LasR is a key QS signal receptor since it acts as a global transcriptional regulator required for optimal expression of main virulence factors. P. aeruginosa modulates the QS response by integrating this cell density-dependent circuit to environmental and metabolic cues. Hence, QS also controls the adaptation to challenging environmental niches, such as infection sites. However, little is known about the molecular mechanisms connecting QS and other signalling pathways. In this work, DNA-affinity chromatography was used to identify new lasR transcriptional regulators. This approach led to the identification and functional characterization of the TetR-like

SUBMITTER: Longo F 

PROVIDER: S-EPMC3702619 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature