Probiotics improve survival of septic rats by suppressing conditioned pathogens in ascites.

ABSTRACT:

Aim

To investigate the benefits of probiotics treatment in septic rats.

Methods

The septic rats were induced by cecal ligation and puncture. The animals of control, septic model and probiotics treated groups were treated with vehicle and mixed probiotics, respectively. The mixture of probiotics included Bifidobacterium longum, Lactobacillus bulgaricus and Streptococcus thermophilus. We observed the survival of septic rats using different amounts of mixed probiotics. We also detected the bacterial population in ascites and blood of experimental sepsis using cultivation and real-time polymerase chain reaction. The severity of mucosal inflammation in colonic tissues was determined.

Results

Probiotics treatment improved survival of the rats significantly and this effect w

SUBMITTER: Liu DQ 

PROVIDER: S-EPMC3703194 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature