Randomised controlled trial of weekly chloroquine to re-establish normal erythron iron flux and haemoglobin recovery in postmalarial anaemia.

ABSTRACT:

Objective

To determine if low-dose weekly chloroquine (CQ) therapy improves recovery from malaria-associated anaemia.

Design

Proof of concept randomised clinical trial.

Setting

West Kiang District, Lower River Region, The Gambia.

Participants

Children resident in participating communities, aged 12-72 months, with uncomplicated malaria identified using active case detection over two consecutive malaria transmission seasons.

Interventions

In 2007, eligible children were randomised to chloroquine-sulfadoxine/pyrimethamine (CQ-SP) or co-artemether (ACT) antimalarial therapy, and after parasite clearance on day 3 were subsequently re-randomised (double-blind) to weekly low-dose CQ (5 mg/kg) or placebo. In 2008, all eligible children were treated with ACT and

SUBMITTER: Cox SE 

PROVIDER: S-EPMC3703580 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature