Proteomic analysis of eccrine sweat: implications for the discovery of schizophrenia biomarker proteins.

ABSTRACT: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) and multiple reaction monitoring mass spectrometry (MRM-MS) proteomics analyses were performed on eccrine sweat of healthy controls, and the results were compared with those from individuals diagnosed with schizophrenia (SZ). This is the first large scale study of the sweat proteome. First, we performed LC-MS/MS on pooled SZ samples and pooled control samples for global proteomics analysis. Results revealed a high abundance of diverse proteins and peptides in eccrine sweat. Most of the proteins identified from sweat samples were found to be different than the most abundant proteins from serum, which indicates that eccrine sweat is not simply a plasma transudate and may thereby be a source of unique disease-associated biomolecules. A

SUBMITTER: Raiszadeh MM 

PROVIDER: S-EPMC3703649 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature