Mycoplasma pneumoniae in children with acute and refractory asthma.

ABSTRACT:

Background

The presence of Mycoplasma pneumoniae has been associated with worsening asthma in children. Sensitive assays have been developed to detect M pneumoniae-derived community-acquired respiratory distress syndrome (CARDS) toxin.

Objectives

To identify the frequency and persistence of M pneumoniae detection in respiratory secretions of children with and without asthma and to evaluate antibody responses to M pneumoniae and the impact of M pneumoniae on biological markers, asthma control, and quality of life.

Methods

We enrolled 143 pediatric patients (53 patients with acute asthma, 26 patients with refractory asthma, and 64 healthy controls; age range, 5-17 years) during a 20-month period with 2 to 5 follow-up visits. We detected M pneumoniae using CARDS toxin an

SUBMITTER: Wood PR 

PROVIDER: S-EPMC3703852 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature