Ontology highlight
ABSTRACT:
SUBMITTER: Weghorn D
PROVIDER: S-EPMC3704022 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Weghorn Donate D Lässig Michael M
Proceedings of the National Academy of Sciences of the United States of America 20130619 27
Histone-DNA complexes, so-called nucleosomes, are the building blocks of DNA packaging in eukaryotic cells. The histone-binding affinity of a local DNA segment depends on its elastic properties and determines its accessibility within the nucleus, which plays an important role in the regulation of gene expression. Here, we derive a fitness landscape for intergenic DNA segments in yeast as a function of two molecular phenotypes: their elasticity-dependent histone affinity and their coverage with t ...[more]