Patterns of FOXE1 expression in papillary thyroid carcinoma by immunohistochemistry.

ABSTRACT:

Background

FOXE1, a thyroid-specific transcription factor also known as TTF-2, was recently identified as a major genetic risk factor for papillary thyroid carcinoma (PTC). Its role in thyroid carcinogenesis, however, remains unknown. The purpose of the present study was to assess the relationship between the FOXE1 immunohistochemical features and the clinical and genetic characteristics of PTC.

Methods

Immunohistochemical staining of FOXE1 was performed in 48 PTC cases. Two single nucleotide polymorphisms immediately inside (rs1867277) or in the vicinity (rs965513) of the FOXE1 gene were genotyped by direct sequencing. Histopathological, clinical, and genetic data were included in statistical analyses.

Results

FOXE1 exhibited cytoplasmic overexpression in tumor tissu

SUBMITTER: Bychkov A 

PROVIDER: S-EPMC3704107 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature