Genetic induction of phosphate toxicity significantly reduces the survival of hypercholesterolemic obese mice.

ABSTRACT:

Objective

The adverse effects of metabolic disorders in obesity have been extensively studied; however, the pathologic effects of hyperphosphatemia or phosphate toxicity in obesity have not been studied in similar depth and detail, chiefly because such an association is thought to be uncommon. Studies have established that the incidence of obesity-associated nephropathy is increasing. Because hyperphosphatemia is a major consequence of renal impairment, this study determines the in vivo effects of hyperphosphatemia in obesity.

Methods and results

We genetically induced hyperphosphatemia in leptin-deficient obese (ob/ob) mice by generating ob/ob and klotho double knockout [ob/ob-klotho(-/-)] mice. As a control, we made ob/ob mice with hypophosphatemia by generating ob/ob and

SUBMITTER: Ohnishi M 

PROVIDER: S-EPMC3704948 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature