Gene expression profiling of blood in ruptured intracranial aneurysms: in search of biomarkers.

ABSTRACT: The molecular mechanisms underlying the systemic response to subarachnoid hemorrhage (SAH) from ruptured intracranial aneurysms (RAs) are not fully understood. We investigated whether the analysis of gene expression in peripheral blood could provide clinically relevant information regarding the biologic consequences of SAH. Transcriptomics were performed using Illumina HumanHT-12v4 microarrays for 43 RA patients and 18 controls (C). Differentially expressed transcripts were analyzed for overrepresented functional groups and blood cell type-specific gene expression. The set of differentially expressed transcripts was validated using quantitative polymerase chain reaction in an independent group of subjects (15 RA patients and 14 C). There were 135 differentially expressed genes (false disco

SUBMITTER: Pera J 

PROVIDER: S-EPMC3705426 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature