Evolutionary dynamics of Vibrio cholerae O1 following a single-source introduction to Haiti.

ABSTRACT:

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Prior to the epidemic that emerged in Haiti in October of 2010, cholera had not been documented in this country. After its introduction, a strain of Vibrio cholerae O1 spread rapidly throughout Haiti, where it caused over 600,000 cases of disease and >7,500 deaths in the first two years of the epidemic. We applied whole-genome sequencing to a temporal series of V. cholerae isolates from Haiti to gain insight into the mode and tempo of evolution in this isolated population of V. cholerae O1. Phylogenetic and Bayesian analyses supported the hypothesis that all isolates in the sample set diverged from a common ancestor within a time frame that is consistent with epidemiological observations. A pangenome analysis showed nearly homogeneous genomic content, with no evidence of

SUBMITTER: Katz LS 

PROVIDER: S-EPMC3705451 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature