Streptomycin-induced inflammation enhances Escherichia coli gut colonization through nitrate respiration.

ABSTRACT: Treatment with streptomycin enhances the growth of human commensal Escherichia coli isolates in the mouse intestine, suggesting that the resident microbial community (microbiota) can inhibit the growth of invading microbes, a phenomenon known as "colonization resistance." However, the precise mechanisms by which streptomycin treatment lowers colonization resistance remain obscure. Here we show that streptomycin treatment rendered mice more susceptible to the development of chemically induced colitis, raising the possibility that the antibiotic might lower colonization resistance by changing mucosal immune responses rather than by preventing microbe-microbe interactions. Investigation of the underlying mechanism revealed a mild inflammatory infiltrate in the cecal mucosa of streptomycin-tre

SUBMITTER: Spees AM 

PROVIDER: S-EPMC3705454 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature