Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis.

ABSTRACT: Proliferation and fusion of myoblasts is a well-orchestrated process occurring during muscle development and regeneration. Although myoblasts are known to originate from muscle satellite cells, the molecular mechanisms that coordinate their commitment toward differentiation are poorly understood. Here, we present a novel role for the transcription factor Forkhead box protein C2 (Foxc2) in regulating proliferation and preventing premature differentiation of activated muscle satellite cells. We demonstrate that Foxc2 expression is upregulated early in activated mouse muscle satellite cells and then diminishes during myogenesis. In undifferentiated C2C12 myoblasts, downregulation of endogenous Foxc2 expression leads to a decrease in proliferation, whereas forced expression of FOXC2 sustains p

SUBMITTER: Gozo MC 

PROVIDER: S-EPMC3705598 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature