Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF).

ABSTRACT: Spirohexenolides A and B comprise a unique family of spirotetronate natural products. We report on the identification of their binding to and modulation of human macrophage migration inhibitor factor (hMIF). Using an immunoaffinity-fluorescent labeling method, the properties of this interaction are detailed and evidence is provided that hMIF plays a key role in the cytostatic activity of the spirohexenolides.

SUBMITTER: Yu WL 

PROVIDER: S-EPMC3706094 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature