Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression.

ABSTRACT:

Context

The endocannabinoid system has been implicated in stress adaptation and the regulation of mood in rodent studies, but few human association studies have examined these links and replications are limited.

Objectives

To examine whether a synonymous polymorphism, rs1049353, in exon 4 of the gene encoding the human endocannabinoid receptor (CNR1) moderates the effect of self-reported childhood physical abuse on lifetime anhedonia and depression and to replicate this interaction in an independent sample.

Design, setting, and participants

Genetic association study in 1041 young US women with replication in an independent Australian sample of 1428 heroin-dependent individuals as cases and 506 participants as neighborhood controls.

Main outcome measures

Self-re

SUBMITTER: Agrawal A 

PROVIDER: S-EPMC3706194 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature