The epidemiological and economic impact of a quadrivalent human papillomavirus (hpv) vaccine in Estonia.

ABSTRACT:

Background

This analysis assessed the epidemiological and economic impact of quadrivalent human papillomavirus (HPV4: 6/11/16/18) vaccination in Estonia.

Methods

A dynamic transmission model was used to assess the epidemiological and economic impact of the routine vaccination of 12-year-old girls with a HPV4 vaccine in preventing cervical cancer, cervical intraepithelial neoplasia (CIN) grades 1, 2 and 3 and genital warts.

Results

The model projected that at year 100, HPV4 vaccination would lead to a reduction of HPV 16/18 related cervical cancer incidence and deaths by over 97% and the incidence of HPV 6/11 related genital warts among Estonian women and men by over 94% and 81%, respectively. The incremental cost-effectiveness ratio of the HPV4 vaccination strategy wa

SUBMITTER: Uuskula A 

PROVIDER: S-EPMC3706227 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature