SAG2A protein from Toxoplasma gondii interacts with both innate and adaptive immune compartments of infected hosts.

ABSTRACT:

Background

Toxoplasma gondii is an intracellular parasite that causes relevant clinical disease in humans and animals. Several studies have been performed in order to understand the interactions between proteins of the parasite and host cells. SAG2A is a 22 kDa protein that is mainly found in the surface of tachyzoites. In the present work, our aim was to correlate the predicted three-dimensional structure of this protein with the immune system of infected hosts.

Methods

To accomplish our goals, we performed in silico analysis of the amino acid sequence of SAG2A, correlating the predictions with in vitro stimulation of antigen presenting cells and serological assays.

Results

Structure modeling predicts that SAG2A protein possesses an unfolded C-terminal end, which var

SUBMITTER: Macedo AG 

PROVIDER: S-EPMC3706231 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature