Genomic adaptation of the ISA virus to Salmo salar codon usage.

ABSTRACT:

Background

The ISA virus (ISAV) is an Orthomyxovirus whose genome encodes for at least 10 proteins. Low protein identity and lack of genetic tools have hampered the study of the molecular mechanism behind its virulence. It has been shown that viral codon usage controls several processes such as translational efficiency, folding, tuning of protein expression, antigenicity and virulence. Despite this, the possible role that adaptation to host codon usage plays in virulence and viral evolution has not been studied in ISAV.

Methods

Intergenomic adaptation between viral and host genomes was calculated using the codon adaptation index score with EMBOSS software and the Kazusa database. Classification of host genes according to GeneOnthology was performed using Blast2go. A non para

SUBMITTER: Tello M 

PROVIDER: S-EPMC3706250 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature