Criteria for assessing high-priority drug-drug interactions for clinical decision support in electronic health records.

ABSTRACT:

Background

High override rates for drug-drug interaction (DDI) alerts in electronic health records (EHRs) result in the potentially dangerous consequence of providers ignoring clinically significant alerts. Lack of uniformity of criteria for determining the severity or validity of these interactions often results in discrepancies in how these are evaluated. The purpose of this study was to identify a set of criteria for assessing DDIs that should be used for the generation of clinical decision support (CDS) alerts in EHRs.

Methods

We conducted a 20-year systematic literature review of MEDLINE and EMBASE to identify characteristics of high-priority DDIs. These criteria were validated by an expert panel consisting of medication knowledge base vendors, EHR vendors, in-house kno

SUBMITTER: Phansalkar S 

PROVIDER: S-EPMC3706355 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature