Linking ClinicalTrials.gov and PubMed to track results of interventional human clinical trials.

ABSTRACT:

Objective

In an effort to understand how results of human clinical trials are made public, we analyze a large set of clinical trials registered at ClinicalTrials.gov, the world's largest clinical trial registry.

Materials and methods

We considered two trial result artifacts: (1) existence of a trial result journal article that is formally linked to a registered trial or (2) the deposition of a trial's basic summary results within the registry.

Results

The study sample consisted of 8907 completed, interventional, phase 2-or-higher clinical trials that were completed in 2006-2009. The majority of trials (72.2%) had no structured trial-article link present. A total of 2367 trials (26.6%) deposited basic summary results within the registry. Of those, 969 trials (10.9%) we

SUBMITTER: Huser V 

PROVIDER: S-EPMC3706420 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature