Upregulation of T-cell factor-4 isoform-responsive target genes in hepatocellular carcinoma.

ABSTRACT:

Background

The Wnt/β-catenin signalling pathway regulates genes involved in cell proliferation, survival, migration and invasion through regulation by T-cell factor (TCF)-4 transcription factor proteins. However, the role of TCF-4 isoforms generated by alternative splicing events in hepatocellular carcinoma (HCC) is unknown.

Aim

Here, we investigated TCF-4 isoforms (TCF-4J and K)-responsive target genes that are important in hepatic oncogenesis and tumour development.

Methods

Gene expression microarray was performed on HCC cells overexpressing TCF-4J and K isoforms. Expression level of selected target genes was evaluated and correlations were made between their expression level and that of TCF-4 isoform in 47 pairs of human HCC tumours.

Results

Comparison by ge

SUBMITTER: Tomimaru Y 

PROVIDER: S-EPMC3706555 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature