Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation.

ABSTRACT: Neurogenesis is thought to play a role in cognitive function and hippocampal plasticity. Previous studies suggest that neurogenesis declines with aging. However, the onset and mechanism of declined neurogenesis are not fully elucidated. Here we show that the major decline in neurogenesis takes place during adulthood, before aging. Decline in neurogenesis takes place in the subgranular layer of the dentate gyrus and in the subventricular zone, and is primarily due to a reduced number of fast-proliferating neural progenitor cells. Importantly, this decline can be rescued by intraventricular injection of recombinant soluble amyloid precursor protein (sAPPα), which regulates neural progenitor cell proliferation in the adult brain. The counterpart, sAPPβ, a product of the amyloidogenic cleavage

SUBMITTER: Demars MP 

PROVIDER: S-EPMC3706568 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature