Mediators of the association between pre-eclampsia and cerebral palsy: population based cohort study.

ABSTRACT:

Objective

To test the hypothesis that pre-eclampsia is a risk factor for cerebral palsy mediated through preterm birth and being born small for gestational age.

Design

Population based cohort study.

Setting

Clinical data from the Norwegian Cerebral Palsy Registry were linked with perinatal data prospectively recorded by the Medical Birth Registry of Norway.

Participants

All singleton babies who survived the neonatal period during 1996-2006 (849 children with cerebral palsy and 616,658 control children).

Main outcome measures

Cerebral palsy and cerebral palsy subtypes.

Results

Children exposed to pre-eclampsia had an excess risk of cerebral palsy (unadjusted odds ratio 2.5, 95% confidence interval 2.0 to 3.2) compared with unexposed children. Among

SUBMITTER: Strand KM 

PROVIDER: S-EPMC3706637 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature