Validation of a novel method for determining the renal threshold for glucose excretion in untreated and canagliflozin-treated subjects with type 2 diabetes mellitus.

ABSTRACT:

Context

The stepwise hyperglycemic clamp procedure (SHCP) is the gold standard for measuring the renal threshold for glucose excretion (RT(G)), but its use is limited to small studies in specialized laboratories.

Objective

The objective of the study was to validate a new method for determining RT(G) using data obtained during a mixed-meal tolerance test (MMTT) in untreated and canagliflozin-treated subjects with type 2 diabetes mellitus (T2DM).

Design

This was an open-label study with 2 sequential parts.

Setting

The study was performed at a single center in Germany.

Patients

Twenty-eight subjects with T2DM were studied.

Interventions

No treatment intervention was given in part 1. In part 2, subjects were treated with canagliflozin 100 mg/d for 8 d

SUBMITTER: Polidori D 

PROVIDER: S-EPMC3706739 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature