A guide to best practices for Gene Ontology (GO) manual annotation.

ABSTRACT: The Gene Ontology Consortium (GOC) is a community-based bioinformatics project that classifies gene product function through the use of structured controlled vocabularies. A fundamental application of the Gene Ontology (GO) is in the creation of gene product annotations, evidence-based associations between GO definitions and experimental or sequence-based analysis. Currently, the GOC disseminates 126 million annotations covering >374,000 species including all the kingdoms of life. This number includes two classes of GO annotations: those created manually by experienced biocurators reviewing the literature or by examination of biological data (1.1 million annotations covering 2226 species) and those generated computationally via automated methods. As manual annotations are often used to pro

SUBMITTER: Balakrishnan R 

PROVIDER: S-EPMC3706743 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature