Differential regulation of gene expression by LXRs in response to macrophage cholesterol loading.

ABSTRACT: The ability of cells to precisely control gene expression in response to intracellular and extracellular signals plays an important role in both normal physiology and in pathological settings. For instance, the accumulation of excess cholesterol by macrophages initiates a genetic response mediated by the liver X receptors (LXRs)-α (NR1H3) and LXRβ (NR1H2), which facilitates the transport of cholesterol out of cells to high-density lipoprotein particles. Studies using synthetic LXR agonists have also demonstrated that macrophage LXR activation simultaneously induces a second network of genes that promotes fatty acid and triglyceride synthesis that may support the detoxification of excess free cholesterol by storage in the ester form. We now show that treatment of human THP-1 macrophages wit

SUBMITTER: Ignatova ID 

PROVIDER: S-EPMC3706843 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature