Expression and Regulation of the Endogenous Retrovirus 3 in Hodgkin's Lymphoma Cells.

ABSTRACT: Human endogenous retroviruses (ERV) are an integral part of our genome. Expression of ERV is usually switched off but reactivation of ERV has been observed in varying human diseases including cancer. Recently, reactivation of ERV associated promoters in Hodgkin's lymphoma (HL) cells has been described. Despite relatively good prognosis, not all patients with HL can be cured with the established therapy and this therapy is associated with severe late side effects. Therefore, new targets are required for the development of future treatment strategies. Reactivated ERV might represent such target structures. Therefore, we asked which ERV loci are expressed in HL cells. Using DNA microarray analysis, we found no evidence for a general activation of ERV transcription in HL cells. In contrast, we

SUBMITTER: Kewitz S 

PROVIDER: S-EPMC3706881 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature