Implications for human leukocyte antigen antibodies after lung transplantation: a 10-year experience in 441 patients.

ABSTRACT:

Background

Long-term survival after lung transplant is limited by the development of chronic and progressive airflow obstruction, a condition known as bronchiolitis obliterans syndrome (BOS). While prior studies strongly implicate cellular rejection as a strong risk factor for BOS, less is known about the clinical significance of human leukocyte antigen (HLA) antibodies and donor HLA-specific antibodies in long-term outcomes.

Methods

A single-center cohort of 441 lung transplant recipients, spanning a 10-year period, was prospectively screened for HLA antibodies after transplant using flow cytometry-based methods. The prevalence of and predictors for HLA antibodies were determined. The impact of HLA antibodies on survival after transplant and the development of BOS were dete

SUBMITTER: Snyder LD 

PROVIDER: S-EPMC3707175 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature