Granulocyte-macrophage colony-stimulating factor autoantibodies: a marker of aggressive Crohn's disease.

ABSTRACT:

Background

Neutralizing autoantibodies (Abs) against granulocyte-macrophage colony-stimulating factor (GM-CSF Ab) have been associated with stricturing ileal Crohn's disease (CD) in a largely pediatric patient cohort (total 394, adult CD 57). The aim of this study was to examine this association in 2 independent predominantly adult inflammatory bowel disease patient cohorts.

Methods

Serum samples from 742 subjects from the NIDDK IBD Genetics Consortium and 736 subjects from Australia were analyzed for GM-CSF Ab and genetic markers. We conducted multiple regression analysis with backward elimination to assess the contribution of GM-CSF Ab levels and established CD risk alleles and smoking on ileal disease location in the 477 combined CD subjects from both cohorts. We also det

SUBMITTER: Gathungu G 

PROVIDER: S-EPMC3707315 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature