A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment.

ABSTRACT:

Rationale

Molecular phenotyping of chronic obstructive pulmonary disease (COPD) has been impeded in part by the difficulty in obtaining lung tissue samples from individuals with impaired lung function.

Objectives

We sought to determine whether COPD-associated processes are reflected in gene expression profiles of bronchial airway epithelial cells obtained by bronchoscopy.

Methods

Gene expression profiling of bronchial brushings obtained from 238 current and former smokers with and without COPD was performed using Affymetrix Human Gene 1.0 ST Arrays.

Measurements and main results

We identified 98 genes whose expression levels were associated with COPD status, FEV1% predicted, and FEV1/FVC. In silico analysis identified activating transcription factor 4 (ATF4) as

SUBMITTER: Steiling K 

PROVIDER: S-EPMC3707363 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature