Adult cardiac expression of the activating transcription factor 3, ATF3, promotes ventricular hypertrophy.

ABSTRACT: Cardiac hypertrophy is an adaptive response to various mechanophysical and pathophysiological stresses. However, when chronic stress is sustained, the beneficial response turns into a maladaptive process that eventually leads to heart failure. Although major advances in the treatment of patients have reduced mortality, there is a dire need for novel treatments for cardiac hypertrophy. Accordingly, considerable efforts are being directed towards developing mice models and understanding the processes that lead to cardiac hypertrophy. A case in point is ATF3, an immediate early transcription factor whose expression is induced in various cardiac stress models but has been reported to have conflicting functional significance in hypertrophy. To address this issue, we generated a transgenic mouse

SUBMITTER: Koren L 

PROVIDER: S-EPMC3707568 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature