Confounding by indication in retrospective studies of intracerebral hemorrhage: antiepileptic treatment and mortality.

ABSTRACT:

Introduction

Intracerebral hemorrhage (ICH) is a highly fatal disease with few proven treatments. Data to guide clinician decisions for therapies, including antiepileptic drugs (AED), are limited. Published studies on AED treatment in ICH have provided conflicting results. We investigated the effect of AED treatment on 90-day mortality after ICH in a large prospectively ascertained cohort.

Methods

We conducted a retrospective analysis of a prospectively assembled cohort of patients with ICH in the supratentorial regions, comparing 90-day mortality and modified Rankin Score among 543 patients treated with AED during hospitalization and 639 AED-free ICH. Supratentorial ICH location was categorized as lobar or deep hemispheric.

Results

Multivariate analysis demonstrated

SUBMITTER: Battey TW 

PROVIDER: S-EPMC3707622 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature