Self-assembled nanoparticles based on modified cationic dipeptides and DNA: novel systems for gene delivery.

ABSTRACT:

Background

Gene therapy is most effective when delivery is both efficient and safe. However, it has often proven difficult to find a balance between efficiency and safety in case of viral or polymeric vectors for gene therapy. Peptide based delivery systems may be attractive alternatives but their relative instability to proteolysis is a major concern in realizing their potential application in biomedical sciences. In this work we report gene delivery potential of nanoparticles (Nps) synthesized from cationic dipeptides containing a non-protein amino acid α, β-dehydrophenylalanine (∆Phe) residue.

Methods

Dipeptides were synthesized using solution phase peptide synthesis method. Nps were formed using self-assembly. Nps were characterized using light scattering, electron micro

SUBMITTER: Panda JJ 

PROVIDER: S-EPMC3707807 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature