Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort.

ABSTRACT:

Background

Little is known about the interaction between genetic and behavioural factors during lifecycle risk periods for obesity and how associations vary across race/ethnicity.

Objective

The objective of this study was to examine joint associations of adiposity-related single-nucleotide polymorphisms (SNPs) and moderate to vigorous physical activity (MVPA) with body mass index (BMI) in a diverse adolescent cohort.

Methods

Using data from the National Longitudinal Study of Adolescent Health (n = 8113: Wave II 1996; ages 12-21, Wave III; ages 18-27), we assessed interactions of 41 well-established SNPs and MVPA with BMI-for-age Z-scores in European Americans (EA; n = 5077), African-Americans (AA; n = 1736) and Hispanic Americans (HA; n = 1300).

Results

Of 97 a

SUBMITTER: Richardson AS 

PROVIDER: S-EPMC3707946 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature