The effects of extended intravenous nicotine administration on body weight and meal patterns in male Sprague-Dawley rats.

ABSTRACT:

Rationale

Increased appetite and weight gain after cessation is a deterrent for quitting smoking. Attempts to understand the mechanism for these effects using animals have been hampered by the difficulty or inconsistency of modeling the effects seen in humans.

Objective

To examine the effects of extended daily access to intravenous nicotine, via programmed infusions, on body weight and meal patterns in rats.

Methods

Intravenous (IV) nicotine infusions (0.06 mg/kg/inf) were administered noncontingently, every 30 min throughout the dark cycle and the last 3 h of the light cycle, to emulate self-administration. The effect of these infusions on food intake, meal patterns, and weight change were examined relative to a control group during treatment and in a post-nicotine p

SUBMITTER: Grebenstein PE 

PROVIDER: S-EPMC3707949 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature