Significant modifications of the salivary proteome potentially associated with complications of Down syndrome revealed by top-down proteomics.

ABSTRACT: People with Down syndrome, a frequent genetic disorder in humans, have increased risk of health problems associated with this condition. One clinical feature of Down syndrome is the increased prevalence and severity of periodontal disease in comparison with the general population. Because saliva plays an important role in maintaining oral health, in the present study the salivary proteome of Down syndrome subjects was investigated to explore modifications with respect to healthy subjects. Whole saliva of 36 Down syndrome subjects, divided in the age groups 10-17 yr and 18-50 yr, was analyzed by a top-down proteomic approach, based on the high performance liquid chromatography-electrospray ionization-MS analysis of the intact proteins and peptides, and the qualitative and quantitative profi

SUBMITTER: Cabras T 

PROVIDER: S-EPMC3708170 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature